Johan Dahlin
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26 lines
816 B
Markdown
26 lines
816 B
Markdown
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date: 2024-08-01
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tags:
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- biokemi
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- provfråga
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- hemoglobin
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---
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**Uppgift**
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How does fetal hemoglobin (HbF) differ from adult hemoglobin (HbA) and what effect does this
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have? (4p)
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OBS! This question needs to be answered in English. (Max. 100 words).
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**Answer**
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Adult hemoglobin consists of two beta subunits and two alfa subunits, while fetal
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hemoglobin consists of two alfa subunits and two gamma subunits. HbA has a
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lower affinity for oxygen than HbF.
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Beta subunits allow for the allosteric regulator 2,3-BPG to bind. when 2,3-bpg
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binds it enhances T-state because it becomes a type of blockage for the
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conformational change to R-state, meaning that the affinity for oxygen is
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lowered. 2,3-BPG cannot bind to the gamma subunits - meaning that the affinity
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for oxygen increases.
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Totalpoäng: 4
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