Johan Dahlin
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20 lines
818 B
Markdown
20 lines
818 B
Markdown
---
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date: 2023-12-18
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tags:
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- biokemi
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- provfråga
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- hemoglobin
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---
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**What does cooperative binding mean? Explain this in the context of hemoglobin. (4p)**
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*OBS! This question needs to be answered in English. (Max 100 words)*
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**Answer**
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```spoiler-block
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Cooperative binding means that the binding of an oxygen to hemoglobin makes it more likely for the molecule to bind more oxygen.
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This is because when an oxygen binds to hemoglobin the structure becomes less tense as one αβ-dimer rotates 15 degrees, which increases its affinity for oxygen at other binding sites.
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Release of an oxygen promotes also further release.
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Due to the cooperativity hemoglobin has a sigmoidal binding curve at different partial pressures of oxygen.
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Cooperativity enables hemoglobin to be a good oxygen transporter.
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```
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