Johan Dahlin
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167 lines
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167 lines
2.3 KiB
Markdown
# Inlärning, Minne och Glömska pdf
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**OCR Transcript**
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- Pages: 14
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- OCR Engine: pymupdf
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- Quality Score: 1.00
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---
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## Page 1
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Inlärning, Minne & Glömska
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Block 4, Eric Hanse
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”Information about the past is useful only to the
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extent that it allows us to anticipate what may
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happen in the future.”
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”The remembered future”
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”The remembered present”
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---
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## Page 2
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”Hebb-synapse”
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Cells that fire together wire together
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”Hebb-synapse”
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”When an axon of cell A is near
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enough to excite cell B and
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repeatedly
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takes part in firing it, some growth
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processor metabolic change takes
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place in one or both cells such that
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A’s efficiency, as one of the cells
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firing B, increases.”
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Donald Hebb, 1949
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---
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## Page 3
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Distributed storgage of memories – Hebb’s cell
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assembly, or the engram
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www.sciencemag.org SCIENCE VOL 338 5 OCTOBER
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2012
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---
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## Page 4
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Synaptic plasticity: Long-term potentiation
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(LTP) and Long-term depression (LTD)
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---
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## Page 5
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Tonegawa et al 2018 Nature Rev Neurosci 19: 485-498
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Activity-dependent labelling of engram cells
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---
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## Page 6
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Hayashi-Takagi et al 2015 Nature 525: 333-338
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---
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## Page 7
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Some synapses grow with LTP and learning…
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and most synapses shrink during sleep
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Cirelli (2017) Curr Op Neurobiol 44:72-76
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Tononi & Cirelli (2014) Neuron 81:12-34
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… creating room for new learning
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---
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## Page 8
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Memories are consolidated and enhanced
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during sleep
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Ji & Wilson, 2006
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---
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## Page 9
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Stickgold and Walker, 2005
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Consolidation and re-consolidation
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---
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## Page 10
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Physiological and pathological forgetting
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Davis and Zhong 2017 Neuron 95: 490-503
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Ryan and Frankland 2022 Nat Rev Neurosci 23:
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---
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## Page 11
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Factors that influence learning
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• Stress
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• Sleep
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• (Re)Consolidation
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• Spaced learning, fasting
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• Physical exercise
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• Active rehearsal
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• Cognitive enhancers?
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Sapolsky 2015 Nat Neurosci 18:1344
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---
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## Page 12
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Subdivision of memories
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Working memory
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---
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## Page 13
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H.M. – Hippocampus is necessary for
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the formation of episodic memories
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H.M’s brain
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Normal brain
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---
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## Page 14
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Amnesia
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Amnesia = patological forgetting
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Procent av normal
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minnesfunktion
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Skada
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tid
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Födsel
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Nutid
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Procent av normal
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minnesfunktion
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Skada
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tid
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Födsel
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Nutid
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Anterograde amnesia
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Retrograde amnesia
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---
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