vault backup: 2025-11-28 09:51:15

content/Biokemi/Gamla tentor/2024-08-01/3.md

@@ -0,0 +1,24 @@
+---
+tags:
+  - biokemi
+  - provfråga
+---
+**Uppgift**
+
+How does fetal hemoglobin (HbF) differ from adult hemoglobin (HbA) and what effect does this
+have? (4p)  
+OBS! This question needs to be answered in English. (Max. 100 words).
+
+**Answer**
+
+Adult hemoglobin consists of two beta subunits and two alfa subunits, while fetal
+hemoglobin consists of two alfa subunits and two gamma subunits. HbA has a
+lower affinity for oxygen than HbF.  
+Beta subunits allow for the allosteric regulator 2,3-BPG to bind. when 2,3-bpg
+binds it enhances T-state because it becomes a type of blockage for the
+conformational change to R-state, meaning that the affinity for oxygen is
+lowered. 2,3-BPG cannot bind to the gamma subunits - meaning that the affinity
+for oxygen increases.  
+
+Ord: 84  
+Totalpoäng: 4