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Johan Dahlin
2025-11-20 21:01:24 +01:00
parent 2fb20dffc4
commit 77fccaa56d
4 changed files with 35 additions and 71 deletions
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92
.idea/workspace.xml generated
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@@ -6,46 +6,8 @@
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@@ -69,12 +31,12 @@
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9
content/.obsidian/workspace.json vendored
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@@ -6,7 +6,7 @@
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3
content/Biokemi/Cellulära processer/Kromatin/Stoff.md
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@@ -1,10 +1,9 @@
``` ```
Upptäckten av nukleosomen gjordes genom {{c1::klyvning av kromatin med DNase I}} följt av {{c2::gelelektrofores som visade 150–200 bp fragment}}.
Nukleosomen består av {{c1::146 bp DNA}} lindat {{c2::1.75 varv}} runt en {{c3::histonoktamer (2×H2A, 2×H2B, 2×H3, 2×H4)}}. Nukleosomen består av {{c1::146 bp DNA}} lindat {{c2::1.75 varv}} runt en {{c3::histonoktamer (2×H2A, 2×H2B, 2×H3, 2×H4)}}.
Histonoktamer består av {{c1::8 histonproteiner}} och har en diameter på {{c2::~11 nm}}. Histonoktamer består av {{c1::8 histonproteiner}} och har en diameter på {{c2::~11 nm}}.
Histoner är extremt konserverade; H4 skiljer sig med {{c1::endast två aminosyror}} mellan ko och ärta över {{c2::1.3 miljarder år}}. Histoner är extremt konserverade; H4 skiljer sig med {{c1::endast två aminosyror}} mellan ko och ärta över {{c2::1.3 miljarder år}}.
Histon H1 binder till {{c1::linker-DNA}} och är nödvändig för bildning av {{c2::30-nm fiber}}. Histon H1 binder till {{c1::linker-DNA}} och är nödvändig för bildning av {{c2::30-nm fiber}}.
Kompakt kromatin hindrar processerna {{c1::transkription}}, {{c2::replikation}}, {{c3::rekombination}} och {{c4::DNA-reparation}}. Kompakt kromatin hindrar processerna {{c1::transkription}}, {{c1::replikation}}, {{c2::rekombination}} och {{c2::DNA-reparation}}.
Histonsvansar består av N-terminala delar på {{c1::H3 och H4}} som kan modifieras för att reglera paktningsgrad. Histonsvansar består av N-terminala delar på {{c1::H3 och H4}} som kan modifieras för att reglera paktningsgrad.
Acetylering neutraliserar positiva laddningar på {{c1::lysin och arginin}} vilket leder till {{c2::lösare bindning till DNA}}. Acetylering neutraliserar positiva laddningar på {{c1::lysin och arginin}} vilket leder till {{c2::lösare bindning till DNA}}.
Histonkoden är {{c1::kombinationen av histonmodifieringar}} som kan {{c2::aktivera eller repressa genuttryck}}. Histonkoden är {{c1::kombinationen av histonmodifieringar}} som kan {{c2::aktivera eller repressa genuttryck}}.

2
quartz.config.ts
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@@ -14,7 +14,7 @@ const config: QuartzConfig = {
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locale: "en-US", locale: "en-US",
baseUrl: "jdahlin.github.io", baseUrl: "jdahlin.github.io",
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