Update
This commit is contained in:
92
.idea/workspace.xml
generated
92
.idea/workspace.xml
generated
@@ -6,46 +6,8 @@
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@@ -69,12 +31,12 @@
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"assignee": "jdahlin"
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@@ -84,28 +46,29 @@
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@@ -137,6 +100,7 @@
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9
content/.obsidian/workspace.json
vendored
9
content/.obsidian/workspace.json
vendored
@@ -6,7 +6,7 @@
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{
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{
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@@ -27,7 +27,7 @@
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{
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@@ -100,7 +100,7 @@
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"width": 200
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@@ -188,7 +188,8 @@
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"direction": "horizontal",
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"width": 200
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"hiddenItems": {
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@@ -1,10 +1,9 @@
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```
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Upptäckten av nukleosomen gjordes genom {{c1::klyvning av kromatin med DNase I}} följt av {{c2::gelelektrofores som visade 150–200 bp fragment}}.
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Nukleosomen består av {{c1::146 bp DNA}} lindat {{c2::1.75 varv}} runt en {{c3::histonoktamer (2×H2A, 2×H2B, 2×H3, 2×H4)}}.
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Histonoktamer består av {{c1::8 histonproteiner}} och har en diameter på {{c2::~11 nm}}.
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Histoner är extremt konserverade; H4 skiljer sig med {{c1::endast två aminosyror}} mellan ko och ärta över {{c2::1.3 miljarder år}}.
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Histon H1 binder till {{c1::linker-DNA}} och är nödvändig för bildning av {{c2::30-nm fiber}}.
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Kompakt kromatin hindrar processerna {{c1::transkription}}, {{c2::replikation}}, {{c3::rekombination}} och {{c4::DNA-reparation}}.
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Kompakt kromatin hindrar processerna {{c1::transkription}}, {{c1::replikation}}, {{c2::rekombination}} och {{c2::DNA-reparation}}.
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Histonsvansar består av N-terminala delar på {{c1::H3 och H4}} som kan modifieras för att reglera paktningsgrad.
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Acetylering neutraliserar positiva laddningar på {{c1::lysin och arginin}} vilket leder till {{c2::lösare bindning till DNA}}.
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Histonkoden är {{c1::kombinationen av histonmodifieringar}} som kan {{c2::aktivera eller repressa genuttryck}}.
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@@ -14,7 +14,7 @@ const config: QuartzConfig = {
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enablePopovers: true,
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locale: "en-US",
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