vault backup: 2026-01-16 12:16:12

content/.obsidian/plugins/image-converter/image-converter-image-alignments.json

@@ -2,14 +2,14 @@
   "Vetenskaplig artikel/Methods & Main Results.md": {
     "aca677ab589429f9db4b9295c7397939": {
       "position": "center",
-      "width": "287px",
-      "height": "302px",
+      "width": "148px",
+      "height": "156px",
       "wrap": false
     },
     "d765982220ac8d6615dac423d5f86ecc": {
       "position": "center",
-      "width": "261px",
-      "height": "285px",
+      "width": "145px",
+      "height": "158px",
       "wrap": false
     }
   }

content/Vetenskaplig artikel/Methods & Main Results.md

@@ -1,9 +1,7 @@
 The aim of the study was to investigate whether normal aging lea. ds to blood cells being produced from fewer cell clones. This was examined by comparing which X chromosome the cells were using between different age groups and between neutrophils and T cells.
-
 In other words, they studied human hematopoiesis across age by analyzing purified blood cell lineages from the subjects.
 
 -----
-
 ## Study
 - 1 97 hematologically normal females
 	- 23 newborn
@@ -11,27 +9,20 @@ In other words, they studied human hematopoiesis across age by analyzing purifie
 	- 80 eldery (over 75)
 - purified neutrofils
 - purified T-cells
-
-
 ----
-
-**Methods**
-
+### Metoder
 1. Peripheral blood samples were collected
 2. Neutrophils and T cells were isolated using cell separation techniques _(centrifugation followed by lineage-specific purification)_
 3. X-chromosome inactivation was analyzed using the HUMARA PCR assay _(PCR-based measurement of which X chromosome is active)_
 4. T cells were analyzed by PCR to check for clonal expansion _(T-cell receptor γ gene rearrangement analysis)_
-
 ---
 ### Results
 1. X chromosome usage is similar in newborns and young adults.
 2. Neutrophils from elderly female individuals show strongly uneven X chromosome usage.
 3. T-cells show much less uneven X chromosome usage and no dominant clonal expansion
-
 ---
-
 ### Cord blood neutrophils
-![[image-183.png|287x302]] 
+![[image-183.png|148x156]] 
 <small>
 - Graph shows the distribution of X chromosome usage in 23 newborn
 - X-axis: % of cells using the less common X chromosome.
@@ -43,7 +34,7 @@ Conclusion: Newborns mostly show balanced use of the two X chromosomes
 
 ### > 75 years neutrophils
 
-![[image-184.png|261x285]]
+![[image-184.png|145x158]]
 <small>
 - This graph shows the purified neutrofils from 80 elderly (y >= 75) females
 - X and Y axis is the same as in previous graph