---
date: 2024-08-01
tags:
  - biokemi
  - provfråga
  - hemoglobin
---
**Uppgift**

How does fetal hemoglobin (HbF) differ from adult hemoglobin (HbA) and what effect does this
have? (4p)  
OBS! This question needs to be answered in English. (Max. 100 words).

**Answer**
```spoiler-block

Adult hemoglobin consists of two beta subunits and two alfa subunits, while fetal
hemoglobin consists of two alfa subunits and two gamma subunits. HbA has a
lower affinity for oxygen than HbF.  
Beta subunits allow for the allosteric regulator 2,3-BPG to bind. when 2,3-bpg
binds it enhances T-state because it becomes a type of blockage for the
conformational change to R-state, meaning that the affinity for oxygen is
lowered. 2,3-BPG cannot bind to the gamma subunits - meaning that the affinity
for oxygen increases.  

```
Totalpoäng: 4