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Johan Dahlin
2025-11-27 10:50:01 +01:00
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content/Biokemi/Cellulära processer/Translation/Stoff.md
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@@ -49,6 +49,13 @@ Alla mRNA molekyler har en signal som definerar början och slutet på varje pol
Initieringsregionen i bakteriellt mRNA innehåller vanligtvis ett startkodon och en purinrik sekvens.
Shine–Dalgarno-sekvensen är en purinrik region som binder till rRNA och placerar startkodonet i P-siten
Bakteriell proteinsyntes initieras av N-formylmethionyl-transfer RNA
Bakteriell initierings-tRNA (tRNA^fMet) släpar med N-formylmethionine till ribosomen
N-formylmethionyl-tRNA is placed in the P site of the ribosome
Initiation factors (IF1, IF2, IF3) assist in the assembly of the protein-synthesizing machinery
IF1 and IF3 bind the 30S subunit to prevent premature binding to the 50S subunit
IF2(GTP) initiator- fMet-tRNA fMet complex binds with mRNA and the 30S subunit to form the 30S initiation complex
70S initiation complex formation is the rate-limiting step in protein biosynthesis
Antibiotic Streptomycin Binds to 30S ribosomal subunit and interferes with the binding of fMet-tRNA fMet (Specific to bacteria)
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