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Johan Dahlin
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content/Biokemi/Gamla tentor/2025-02-01/4.md
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---
date: 2025-02-01
tags:
- biokemi
- provfråga
- hemoglobin
---
**Uppgift**
A) Name two allosteric regulators of oxygen binding to hemoglobin.
B) Explain an outcome for each regulator.
(Max 100 words.) Please answer this question in English. (4p)
**Answer**
```spoiler-block
a) O₂ and CO₂
b)
O₂:
Hemoglobin has four subunits that bind to O₂ through cooperativity, meaning that if one subunit binds to an O₂, the other subunits' affinity for O₂ will increase, leading to all subunits binding to O₂. When O₂ binds, the state goes from T-state (deoxy; tense) to R-state (oxy; relaxed).
CO₂:
When CO₂ binds to hemoglobin, the hemoglobin's affinity to oxygen decreases, leading to a stabilization of the T-state instead.
```
Totalpoäng: 4