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--- a/tentor/2024-08-01/3.md
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---
-date: 2024-08-01
-tags:
-  - biokemi
-  - provfråga
-  - hemoglobin
---
-**Uppgift**
-
-How does fetal hemoglobin (HbF) differ from adult hemoglobin (HbA) and what effect does this
-have? (4p)  
-OBS! This question needs to be answered in English. (Max. 100 words).
-
-**Answer**
-```spoiler-block
-
-Adult hemoglobin consists of two beta subunits and two alfa subunits, while fetal
-hemoglobin consists of two alfa subunits and two gamma subunits. HbA has a
-lower affinity for oxygen than HbF.  
-Beta subunits allow for the allosteric regulator 2,3-BPG to bind. when 2,3-bpg
-binds it enhances T-state because it becomes a type of blockage for the
-conformational change to R-state, meaning that the affinity for oxygen is
-lowered. 2,3-BPG cannot bind to the gamma subunits - meaning that the affinity
-for oxygen increases.  
-
-```
-Totalpoäng: 4