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Johan Dahlin
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content/Biokemi/Gamla tentor/2023-05-15/4.md
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---
date: 2023-05-15
tags:
- biokemi
- provfråga
- hemoglobin
---
Nämn de allosteriska regulatorerna för hemoglobin och ange om de höjer eller sänker hemoglobinets syreaffinitet. (2p) Max 25 ord.
**Svar**
```spoiler-block
CO₂: bildar kolsyra & karbamatjoner, sänker pH.
H⁺: interagerar med sidokedjor, uppstår jonbindningar.
2,3-BPG: binder subenheterna, förhindrar konformationsändring.
Samtliga stabiliserar T-state, sänker affiniteten för syre.
```