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The aim of the study was to investigate whether normal aging lea. ds to blood cells being produced from fewer cell clones. This was examined by comparing which X chromosome the cells were using between different age groups and between neutrophils and T cells. The aim of the study was to investigate whether normal aging leads to blood cells being produced from fewer cell clones. This was examined by comparing which X chromosome the cells were using between different age groups and between neutrophils and T cells.
In other words, they studied human hematopoiesis across age by analyzing purified blood cell lineages from the subjects. In other words, they studied human hematopoiesis across age by analyzing purified blood cell lineages from the subjects.
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</small> </small>
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### > 75 years neutrophils ### > 75 years neutrophils
![[image-184.png|145x158]] ![[image-184.png|145x158]]
@@ -40,3 +39,11 @@ Conclusion: Newborns mostly show balanced use of the two X chromosomes
- X and Y axis is the same as in previous graph - X and Y axis is the same as in previous graph
Conclusion: Elderly neutrophils frequently show strongly uneven X chromosome usage. Conclusion: Elderly neutrophils frequently show strongly uneven X chromosome usage.
</small> </small>
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