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content/Vetenskaplig artikel/Methods & Main Results.md
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The aim of the study was to investigate whether normal aging leads to blood cells being produced from fewer cell clones. This was examined by comparing which X chromosome the cells were using between different age groups and between neutrophils and T cells.
The aim of the study was to investigate whether normal aging lea. ds to blood cells being produced from fewer cell clones. This was examined by comparing which X chromosome the cells were using between different age groups and between neutrophils and T cells.
In other words, they studied human hematopoiesis across age by analyzing purified blood cell lineages from the subjects.
-----
Modell/material
- 197 hematologically normal females
- 23 new born
## Study
- 1 97 hematologically normal females
- 23 newborn
- 94 young adult (median 30)
- 80 eldery (over 75)
- purified neutrofils
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---
### Figure
![[image-183.png|177x186]]
Notes
- This graph shows the distribution of X chromosome usage in 23 newborn females
- X-axis: the % of cells using the less common X chromosome.
- 50% means perfectly (50% maternal / 50% paternal)
- 0/100% means all cells use the same chromosome
- Y-axis: number of individuals in each group
### Cord blood neutrophils
![[image-183.png|287x302]]
<small>
- Graph shows the distribution of X chromosome usage in 23 newborn
- X-axis: % of cells using the less common X chromosome.
- Y-axis: number of individuals in each group.
Conclusion: Newborns mostly show balanced use of the two X chromosomes
</small>
Conclusion:
- Newborns mostly show balanced use of the two X chromosomes.
---
![[image-184.png|177x193]]
Notes
### > 75 years neutrophils
![[image-184.png|261x285]]
<small>
- This graph shows the purified neutrofils from 80 elderly (y >= 75) females
- X and Y axis is the same as in previous graph
Conclusion:
- Elderly neutrophils frequently show strongly uneven X chromosome usage.
Conclusion: Elderly neutrophils frequently show strongly uneven X chromosome usage.
</small>