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---
tags:
- biokemi
- translation
- instuderingsuppgifter
föreläsare: Ana Luis
---
## Genetic code
#### Describe the main features of the genetic code.
#### What is degeneracy of the genetic code and what its biological significance?
## Translation and tRNA
#### What is translation?
#### What is a tRNA and what is its function in protein synthesis?
#### What are the general characteristics of a tRNA?
#### Why the 3 CCA terminal region in a tRNA is also know as the acceptor arm?
#### What is the wobble effect and which base in the anticodon determines the wobble effect?
#### Explain why aminoacyl-tRNA synthetases are the true reads of the genetic code?
#### How do aminoacyl-tRNA synthetases work? Describe active and editing sites.
## Ribosomes
#### What is a ribosome and what are its different components?
#### Which components of the ribosome are critical to its structure and function?
#### Describe the three binding sites (A, P, and E) and which tRNAs are found in each site.
#### What are the differences between bacterial and eukaryotic ribosomes?
#### How can the ribosome be used as a structure to development of new antibiotics?
## Protein translation mechanism
#### What are the steps of protein translation?
#### What are the characteristics of the initiation region in bacteria?
#### Explain why the reading frame is establish during the initiation step of protein synthesis?
#### How does protein initiation start and what role initiation factors play?
#### What is the role of elongation and translocation factors?
#### What is the role of release factors in protein synthesis?
#### What is a polysome and what is its biological significance?
#### What are the differences between bacteria and eukaryotic protein biosynthesis?
#### Streptomycin is a bacterial antibiotic that blocks protein biosynthesis. Describe how this antibiotic works and which step of protein biosynthesis is inhibited.