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@@ -14,7 +14,7 @@ methods:
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3. T-cell clonality check
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> [!NOTE]
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> They separated neutrophils and T cells, measured X-inactivation skewing, and checked that T-cells were not dominating.
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> They separated neutrophils and T cells, measured X-inactivation skewing, and checked that T cells were not dominating.
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### **What was compared / tested**
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@@ -32,7 +32,7 @@ methods:
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![[image-183.png|177x186]]
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Notes
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- This graph shows the distribution of X chromosome usage in 23 newborn females
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- X-axis: in % how uneven the X chromosome usage is
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- X-axis: the % of cells using the less common X chromosome.
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- 50% means perfectly (50% maternal / 50% paternal)
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- 0/100% means all cells use the same chromosome
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- Y-axis: number of individuals in each group
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@@ -43,8 +43,7 @@ Conclusion:
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![[image-184.png|177x193]]
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Notes
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- This graph shows the purified neutrofils from 80 elderly (y >= 75) females
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-
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- X and Y axis is the same as in previous graph
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Fig 1. Distribution of X-chromosome inactivation patterns from peripheral blood of haematologically normal females in three different age groups
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Conclusion:
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- Elderly neutrophils frequently show strongly uneven X chromosome usage.
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